Home » Research » Basic Research » 1A: Coordination of endocytosis and signaling in time and space

RESEARCH TOPICS

Basic Research

Function of the vesicle trafficking machinery

1A) Coordination of endocytosis and signaling in time and space.

 Overview of major findings in this area.

Bem3, a Cdc42 GTPase-activating protein, traffics to an intracellular compartment and recruits the secretory Rab GTPase Sec4 to endomembranes. Mukherjee D, Sen A, of the ENTH domain from yeast epsin Ent2 that induces a cell division phenotype. Costakes GT, Sen A, Aguilar RC, Stauffacher CV. Protein Sci. 2013 Jun;22(6):755-61. Boettner DR, Fairn GD, Schlam D, Valentin FJB, McCaffery JM, Hazbun T, Staiger CJ, Grinstein S, Lemmon SK, Aguilar RC. Journal of cell science 126 (20), 4560-4571

RhoGTPase-binding proteins, the exocyst complex and polarized vesicle trafficking. Mukherjee D, Sen A, Aguilar RC. Small GTPases. 2014;5:e28453. doi: 10.4161/sgtp.28453.

Bem3: Filling the GAP between cell polarity and secretion. Sen A, Mukherjee D, Aguilar RC. Commun Integr Biol. 2013 Nov 1;6(6):e26702.

Crystallographic analysis of the ENTH domain from yeast epsin Ent2 that induces a cell division phenotype. Costakes GT, Sen A, Aguilar RC, Stauffacher CV. Protein Sci. 2013 Jun;22(6):755-61.

Purdue University Center for Cancer Research
Purdue University Institute for Drug Discovery
Purdue University Institute for Integrative Neuroscience
Purdue Institute of Inflammation, Immunology and Infectious Disease
Purdue University Center for Science of Information
PULSE