Cramer Lab

Publications: Colicins, Receptors, Channels, Import

Colicins, Receptors, Channels, Import


Recent Abstracts
  1. Yamashita, M. V. Zhalnina, Sharma, O., S. D. Zakharov, and W. A. Cramer. 2008. The outer membrane translocon for nuclease colicins: higher resolution of the OmpF porin. Abstr. 52nd Ann. Mtg. Biophys. Soc., Long Beach, CA. p. 375a.
  2. Zakharov S. D., Y. N. Antonenko, A. A. Sobko, E. A. Dutseva, J. D. Hulleman, J.-C. Rochet, and W. A. Cramer. 2008. Monomeric helical a-synuclein forms highly conductive ion channels. Abstr. 52nd Ann. Mtg. Biophys. Soc., Long Beach, CA. p. 612a.
  3. Zakharov, S. D., E. Dutseva, J. D. Hulleman, Y. N. Antonenko, J.-C. Rochet, and W. A. Cramer. 2007. Is monomeric “alpha-synuclein able to form ion channels? Abstr. 52nd Ann. Mtg. Biophys. Soc., Baltimore, MD, p. 396a.
  4. Sharma, O., E. Yamashita, M. V. Zhalnina, S. D. Zakharov, and W. A. Cramer. 2007. Entry of nuclease E colicins through the BtuB-OmpF translocon. Abstr. 52nd Ann. Mtg. Biophys. Soc., Baltimore, MD, p. 435a.
  5. Spector, J., S. Zakharov, O. Sharma, W. A. Cramer, and K. Ritchie. 2007. Single molecule fluorescence tracking of individual BtuB-Colicin complexes in the outer membrane of E. coli. Abstr. 52nd Ann. Mtg. Biophys. Soc., Baltimore, MD, p. 528a.
Publications
  1. Zakharov, S. D., O. Sharma, O., M. Zhalnina, and W. A. Cramer (2008) Primary Events in the Colicin Translocon: FRET Analysis of Colicin Unfolding Initiated by Binding to BtuB and OmpF. Biochemistry 47,12802-12809.
  2. Yamashita, E., M. V. Zhalnina, S. D. Zakharov, O. Sharma, and W. A. Cramer (2008) Crystal structures of the OmpF porin: function in a colicin translocon. EMBO J., 27, 2171-2180
  3. Zakharov, S. D., J. D. Hulleman, E. A. Dutseva, Y. N. Antonenko, J.-C. Rochet, and W. A. Cramer. 2007. Helical a-Synuclein Forms Highly Conductive Ion Channels. Biochemistry, 46, 14369-14379.
  4. Sharma, O., E. Yamashita, M. Zhalnina, S. D. Zakharov, K. Datsenko, B. L. Wanner, and W. A. Cramer. 2007. Structure of the Complex of the Colicin E2 R-Domain and Its BtuB Receptor: The Outer Membrane Colicin Translocon. J. Biol. Chem, 282:23163-23170.
  5. Sharma, O., and W. A. Cramer. 2007. Minimum length requirement of the flexible N-terminal translocation sub-domain of colicin E1. J. Bacteriol., 189: 363-368.
  6. Zakharov, S. D., M. V. Zhalnina, O. Sharma, and W. A. Cramer. 2006. The Colicin E3 Outer Membrane Translocon: Immunity Protein Release Allows Interaction of Cytotoxic Domain with OmpF Porin. Biochemistry, 45: 10199-10207.
  7. Sharma, O., S. D. Zakharov, and W. A. Cramer. 2006. Colicins: Section on Bacterial/Antibiotic Peptides (ed., R. E. W. Hancock) in Handbook of Biologically Active Peptides. (A. J. Kastin, ed.), pp. 115-123, Elsevier, San Diego
  8. A. A. Sobko, A. A., Elena A. Kotova, Yuri N. Antonenko, Stanislav D. Zakharov, and William A. Cramer. 2006. Lipid Dependence of the Channel Properties of Colicin E1 - Lipid Toroidal Pore. J. Biol. Chem., 281:14408-14416.
  9. Zhang, H., & W. A. Cramer. 2005. Problems in obtaining diffraction-quality crystals of hetero-oligomeric integral membrane proteins. J. Struct. Funct. Genomics (NIGMS Protein Production and Crystallization Workshop), 6: 219-223.
  10. Misquitta, L. V., Y. Misquitta, V. Cherezov, O. Slattery, J. M. Mohan, D. Hart, M. Zhalnina, W. A. Cramer, and M. Caffrey. 2004. Membrane protein crystallization in lipidic mesophases with tailored bilayers. Structure: 12: 2113-2124.
  11. A. A. Sobko, M. A. Vigasina, T. I. Rokitskaya, E. A. Kotova, S. D. Zakharov, W. A. Cramer, and Y. N. Antonenko. 2004. Chemical and Photochemical Modification of Colicin E1 and Gramicidin A in Bilayer Lipid Membranes. J. Mem. Biol., 199: 51-62.
  12. Zakharov, S. D., V. Eurokova, T. I. Rokitskaya, M. V. Zhalnina, O. Sharma, P. J. Loll, H. I. Zgurskaya, Y. N. Antonenko, and W. A. Cramer. 2004. Colicin Occlusion of OmpF and TolC Channels: Outer Membrane Channels for Colicin Import.Biophys. J., 87: V.87. 3901-3911.
  13. Zakharov, S. D., E. A. Kotova, Y. N. Antonenko, and W. A. Cramer. 2004. On the role of lipid in colicin pore formation. Biochim. Biophys. Rev. Biomembranes, 1666: 239-249.
  14. Sobko, A., E. A. Kotova,Y. Antonenko, S. D. Zakharov, & W. A. Cramer. 2004. Effect of lipids with different spontaneous curvature on the channel activity of colicin E1: evidence in favor of a toroidal pore. FEBS Lett., 576: 205-210.
  15. Zakharov, S. D. & W. A. Cramer 2004.On the pathway & mechanism of colicin import across the outer membrane. Frontiers in Science, 9: 1311-1317.
  16. Kurisu, G., S. D. Zakharov, M. V. Zhalnina, S. Bano, Y Eroukova, T. Rokitskaya, Y Antonenko, M. C. Wiener & W. A. Cramer. 2003. The structure of BtuB with bound colicin E3 R-domain implies a translocon. Nat. Struct Biol., 10: 948-954.
  17. Zakharov, S. D., T. I. Rokitskaya, Y. N. Antonenko, & W. A. Cramer. 2002. Tuning the membrane surface potential for colicin channel activity. Proc. Natl. Acad. Sci., USA, 99: 8654-8659
  18. Zakharov, S. D., and WA Cramer. 2002. Colicin crystal structures: pathways and mechanisms for colicin insertion into membranes. Biochim. Biophys. Acta (Biomembranes), 1565: 333-346.
  19. Zakharov, S. D., & W. A. Cramer. 2002. The insertion intermediates of pore-forming colicins in two-dimensional space. Biochimie (special issue on Bacterial-Derived Antimicrobial Toxins; eds., R. Buckingham, M. de Zamaroczy, & Y. Cenatiempo), 84: 465-475.
  20. Rokitskaya, T. I., Zakharov, S. D., Y. N. Antonenko, E. A. Kotova, and W. A. Cramer. 2001. Tryptophan-dependent sensitized photoinactivation of colicin E1 channels in lipid bilayers. FEBS Lett.,505: 147-150.
  21. Lindeberg, M. L., & W. A. Cramer. 2001. Identification of Specific Residues in Colicin E1 Involved in Immunity Protein Recognition. J. Bacteriol. 183: 2132-2136.
  22. Griko, Y., S. D. Zakharov, and W. A. Cramer 2000. Structural stability and domain organization of colicin E1. J. Mol. Biol. 302: 941-953.
  23. Taylor, R., S. D. Zakharov, J. B. Heymann, M. E. Girvin, and W. A. Cramer. 2000. Folded state of the integral membrane colicin E1 immunity protein in solvents of mixed polarity. Biochemistry 39: 12131-12139.
  24. Lindeberg, M. and W. A. Cramer. 2000. Pathway of unfolding of the colicin E1 channel domain at the membrane surface. J. Mol. Biol. 29: 679-692.
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