Graduate Courses

BIOL 51101 X-Ray Crystallography

Session Offered:

Spring Credit 3.0

Prerequisites:

Description:

This course will provide an introduction to structure determination of macromolecules using X-ray crystallography and will attempt to balance theory and practice, consisting of ~60% lectures and ~40% lab modules. The course is divided into five 3-week modules covering (i) Crystallization, (ii) Data Collection, (iii) Molecular Replacement, (iv) Experimental Phasing, and (v) Model Building and Refinement, Validation, and Visualization. The goal of the course is to equip students with the necessary tools to develop and execute an X-ray crystallography project, starting from construct design to publication. By the end of the course, students should be familiar with the (i) structure determination pipeline, (ii) theory behind X-ray diffraction methods, (iii) methods for crystallization, (iv) phasing options for solving a crystal structure, and (v) contemporary crystallography software. 

Instructor(s):

NICHOLAS NOINAJ

E-mail:

Textbook(s):

Spring Textbook list PDF Word

Course Format:

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